Ancient DNA Finally Solves the Mystery of the World’s First Pandemic

Scientists have finally uncovered direct genetic evidence of Yersinia pestis — the bacterium behind the Plague of Justinian — in a mass grave in Jerash, Jordan. This long-sought discovery resolves a centuries-old debate, confirming that the plague that devastated the Byzantine Empire truly was caused by the same pathogen behind later outbreaks like the Black Death.

For the first time, researchers have uncovered direct genomic evidence of the bacterium behind the Plague of Justinian – the world’s first recorded pandemic – in the Eastern Mediterranean, where the outbreak was first described nearly 1,500 years ago.

The landmark discovery, led by an interdisciplinary team at the University of South Florida and Florida Atlantic University, with collaborators in India and Australia, identified Yersinia pestis, the microbe that causes plague, in a mass grave at the ancient city of Jerash, Jordan, near the pandemic’s epicenter. The groundbreaking find definitively links the pathogen to the Justinian Plague marking the first pandemic (AD 541-750), resolving one of history’s long-standing mysteries.

Searching for Definite, Not Probable Cause

For centuries, historians have deliberated on what caused the devastating outbreak that killed tens of millions, reshaped the Byzantine Empire and altered the course of Western civilization. Despite circumstantial evidence, direct proof of the responsible microbe had remained elusive – a missing link in the story of pandemics.